Exploring the Capability of Indonesia Natural Medicine Secondary Metabolite as Potential Inhibitors of SARS-CoV-2 Proteins to Prevent Virulence of COVID-19: In silico and Bioinformatic Approach

BACKGROUND: SARS-CoV-2 was causing COVID-19 disease resulting in many deaths and being a significant concern the world today. There is an emergent need to search for possible medications treatment. The key point halt infection through inhibition of virus-receptor interaction stimulates immune system. Utilization bioinformatic silico molecular docking number available might be proven effective inhibiting main drug targets including SARS-CoV2 spike glycoprotein, 3CL protease active target, PD-ACE2, 2019-nCoV PLpro, NF-k?. AIM: This present study conducted identify potential target mechanism major compound on Alpinia galanga extract Citrus sinensis (L.) circumventing using bioinformatics approach docking. RESULTS: Direct protein all secondary metabolite gene list from PubMed “Severe acute respiratory syndrome coronavirus 2” generated 2 genes (CCL2 VEGFA) as therapeutics (PTTG). by Protein-Ligand Ant System (PLANTS) software. results show that hesperidin, naringenin, galangin have lower score five-protein receptor compared with chloroquine remdesivir. suggests high affinity bind protein. Moreover, these compounds strong their inhibitory capacity viral infection. CONCLUSION: In general, this study’s findings dan exhibit best inhibitor development inhibited cytokine storm inactivation NF-k? _pathway.